Judge Ginsburg was appointed to the United States Court of Appeals for the District of Columbia in 1986; he served as Chief Judge from 2001 to 2008. After receiving his B.S. from Cornell University in 1970, and his J.D. from the University of Chicago Law School in 1973, he clerked for Justice Thurgood Marshall on the United States Supreme Court.

Thereafter, Judge Ginsburg was a full professor at the Harvard Law School, Administrator of the Office of Information and Regulatory Affairs (OMB), and Assistant United States Attorney General in charge of the Antitrust Division of the U.S. Department of Justice.  Concurrent with his service on the federal bench, Judge Ginsburg has taught at the University of Chicago Law School and the New York University School of Law. Judge Ginsburg is currently a Professor of Law at the Antonin Scalia Law School, George Mason University, and a visiting professor at University College London, Faculty of Laws.

He also serves on the Advisory Boards of the Harvard Journal of Law and Public Policy; the Supreme Court Economic Review; the University of Chicago Law Review; the New York University Journal of Law and Liberty; and, at University College London, both the Center for Law, Economics and Society and the Jevons Institute for Competition Law and Economics. 

In 2020, Judge Ginsburg created and hosted, A More or Less Perfect Union, a three-part series about the U.S. Constitution. It aired nationwide on public television three times that year. The following year, he partnered with izzit.org® to create Civics Fundamentals, an educational series consisting of 100 two-minute videos based on the 100 questions on the U.S. Citzenship Test. In the videos, Judge Ginsburg provides the answer, as well as the context for each question. Available Fall 2021, the videos will be available at no cost to educators.